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Top 7 Alternatives of Apoquel for Dogs

Is There An Alternative to Apoquel for Dogs?

Many veterinarians shy away from Apoquel usage because, in most of the cases, it’s impossible to stop the dogs from becoming an addict of Apoquel. It stops the itching by compromising the immune reaction of the dogs and not by eliminating the root cause. And this is why as soon as Apoquel dosage is stopped, the allergies resurface again. Fortunately, there are following alternatives which you can give your dog instead of Apoquel. They are as effective as Apoquel but without any potential side effects.

Ø Vet’s Best Shed and Itch Healthy Coat

Ø Vet’s Best Hot Spot Spray

Ø Zesty Paws Allergy Immune Bites

Ø Prosense Itch and Allergy Solution

Ø Vet’s Best Seasonal Allergy Support

Ø Zesty Paws Coconut Oil

Ø Alpha Pet Zone Ultimate Pet Healer

1. Zesty Paws Allergy Immune Bites

If you are looking for an ultimate alternative of Apoquel which solves all the allergy problems in your dog, then Zesty Paws Immune Allergy Immune Bites is the best solution. Unlike Apoquel, it helps in protecting the dogs from seasonal skin allergies by balancing the immune system rather than suppressing it. It is made with Wild Alaskan Solomon Oil which is rich in Omega-3 fatty acids and DHA. They improve the immune system in dogs and make them stronger against allergy-causing hot spots and itchiness.

They also contain EpiCor which provides the dogs with fibers, proteins, vitamins, antioxidants, and all the other nutrients which have been proved to improve the dogs’ natural defenses against pests and diseases.

Unhealthy digestion also promotes the allergy-causing factors, and this is why Zesty Paws Allergy Immune bites contain Colostrums, a natural nourishing ingredient that enhances digestion and immune functioning.

Other components of these Immune Bites are the Probiotic and Prebiotic complex with 250 million CFU of healthy microorganisms, Apple vinegar, and Licorice Extract for coating against allergies.

Pros of Zesty Paws Immune Bites

Ø It enhances the immune and digestive system of dogs so they can fight against food, skin and seasonal allergies.

Ø The unique blend of antioxidants, nutrients and Probiotics strengthens the digestive system of dogs.

Ø Omega-3 fatty acids improve skin conditions and boost immunity.

Ø Epicor provides fibers, proteins, vitamins and antioxidants which make the skin healthy and allergy-repellent.

Ø It is available in multiple flavors such as Hemp-cheese, Lamb and Peanut Butter.


Ø The overdose of these immune bites can be very harmful.

Ø There are cases where dogs were reported to develop diarrhea and vomiting after the intake of these Immune Bites.

Ø It cannot be given to pregnant and breeding dogs.

Ø It can affect the daily routine and eating pattern of the dog.

2. Vet’s Best Hot Spot Spray

The greatest plus point of Vet’s Best Hot Spot Spray is that it is made up of only plant-based ingredients and so you don’t need to worry about the toxic effect of chemicals.

It helps by providing immediate relief in red skin, itchy skin, hot spots, and skin irritation.

The unique combination of natural ingredients such as Aloe Vera, tea tree oil and Chamomile results in effective and quick action.

Aloe Vera is rich in vitamin A, B, C, D, E and amino acids. It maintains the quality of the skin and provides a protective coat against the itching. It also contains a carbohydrate called Acemannan which prevents the skin from getting dry.

Tea tree oil helps in fighting seasonal allergies by improving the immune system and boosting the quality of the skin.

Chamomile contains antioxidants which help in protecting against environmental pollution and attacks of free radicals.

It is hundred per cent steroid-free and does not contain Hydrocortisone.


Ø It is a powerful spray and provides instant relief from itchiness and dry skin.

Ø It contains only plant-based ingredients and no chemicals.

Ø It doesn’t contain alcohol and uses a no-sting formula.

Ø It doesn’t affect the tick control and topical flea resistance.

Ø It is completely steroid-free.

Ø It can be given to all dogs more than a year old.


Ø It can be very harmful if it comes in contact with eyes.

Ø It shouldn’t be used for pregnant and nursing dogs.

Ø Ingestion can be very dangerous as tea tree oil is considered as a toxic.

3. Vet’s Best Healthy Coat and Shed

Vet’s Best Healthy Shed and Coat helps your dog by eliminating the problems of dry and itchy skin completely.

It is made up of hundred per cent natural ingredients such as yellow dock roots, MSM, quercetin, Omega-3 acids, Omega-6 acids, and Nettle leaves.

Omega-3 fatty acids: These fatty acids are considered as the fundamental building block of healthy skin tissues. They keep the skin hydrated and increase the shedding of dead and damaged skin cells. They act like an additional coat which combats external disturbances.

Yellow Dock roots: Antioxidants is what this natural herb is rich in. Antioxidants help in maintaining the quality of skin and provide a coat against harmful external agents and attacks of free radicals. They also improve the immune system in dogs.

MSM: It proves to be very effective in seasonal allergies by maintaining the right histamine levels in the skin of the dogs.

Nettle Leaf: It is a plant with green leaves and purple flowers, and in addition to combating seasonal allergies, it helps in maintaining the moisture content in the skin.

Pros of Vet’s Best Healthy Shed and Coat

Ø It is fit for all types of mature dogs.

Ø It helps in creating a coat against harmful external agents and maintaining the moisture level in the skin.

Ø It reduces red skin and hot spots.

Ø It is very effective in relieving seasonal allergies.

Ø The tablets are tasty and easily chewable. These are also very easy to break.

Ø You can give the tablet to your dog by either mixing in its food or wrapping with some delicious dish.


Ø The effects may take considerable time to appear.

Ø Some dogs may refuse to take it.

Ø It is not fit for pregnant and lactating dogs.

Ø Overdose can be very harmful.

4. Vet’s Best Seasonal Allergy Relief

As the name suggests, Vet’s Best Seasonal Allergy Relief is very effective in combating seasonal allergies which cause excessive itching of dogs.

It is hundred per cent natural alternative of Apoquel and it contains only natural ingredients such as Perilla leaf, nettle leaves, quercetin, and citrus.

Perilla Leaf: This Himalayan herb not only adds aroma and taste in dishes but is also rich in antioxidants which help the dogs in resisting environmental pollution.

Quercetin: It is also very rich in antioxidants and increases the histamine levels in dogs so they can fight against seasonal allergies. It also protects the dogs from the attacks of free radicals and boosts their immune system.

Nettle Extracts: This green-leaved plant improves the immune system of dogs. It maintains adequate moisture in the skin and provides a coating against seasonal allergies.

Citrus Boiflavonoid Complex: Citrus fruits are rich in Vitamin C which increases metabolism and thus improves digestion. It is also a rich source of antioxidants that improve the respiratory health in dogs and gives them the power to resist environmental stress. It fights free radicals and improves the quality of blood cells.

Pros of Vet’s Best Seasonal Allergy Relief

Ø It can be given to all dogs that over one year of age.

Ø It provides a lot of antioxidants in the body which improve immunity and help the dogs fight seasonal allergy.

Ø It helps in maintaining the right histamine level and thus protecting the quality of the skin.

Ø The tablets are tasty and easy to chew.

Ø For varying doses, you can easily break the tablets.

Ø You can mix the tablet in your dog’s food or wrap it in cheese or any similar dish.


Ø It is not very effective in food allergies.

Ø Some dogs are reported with the problems of vomiting and diarrhea.

Ø The results may take some time to appear.

Ø It is not for breeding and pregnant dogs.

5. Prosense Itch and Allergy Solution for Pets

Prosense Itch and Allergy Solution for pets provide relief to your dog’s itching problems. An Excessive level of histamine is known to trigger allergy and inflammation in animals, and Prosense Itch and Allergy Solution acts by blocking the histamine.

It is beneficial in reducing your dog’s allergy sensitivity problems such as continuous itching, sneezing, runny nose, and watery eyes.

This solution can deal with the entire allergy causing sources such as dander, fabrics, pollens and fleas, and limit their actions so that your dog can feel comfortable.

For dogs weighing more than 15lbs, you can give them half tablet of Prosense Itch and Allergy Solution two times a day. For maximum results, you can bathe your dog with Prosense Hydrocortisone Shampoo which contains Aloe Vera and is completely alcohol-free.


Ø It blocks excessive histamine level which is known to trigger allergies.

Ø It works very quickly in reducing itching, sneezing, runny nose and watery eyes.

Ø It can deal with all types of allergens.

Ø It comes in easy to use bottles.


Ø If you are already giving your dog some medicine containing diphenhydramine, then don’t give Posense Itch and Allergy Solution.

Ø The results may take time to appear.

Ø Rival and cheaper brands are available in the market.

6. Zesty Paws Coconut Oil for Dogs

Coconut oil is famous for its digestion-boosting properties and it also helps in brain development. It improves the immune system in dogs along with maintaining the freshness of their breath.

Zesty Paws Coconut Oil is made of hundred per cent organic extract which are fit for both internal consumption and external application on the skin.

It acts as an Anti-itch topical solution. The coconut oil reduces irritation causing red spots and itchiness resulting from flea bites. It also reduces the dryness level of the skin by keeping the skin hydrated and dandruff-free.

It enhances the shine and strength by providing nourishment to the dog coats which can become matted, dull and dry over time. It keeps the fur soft and reduces their shedding.

It contains MCT fatty acids which not only improves the quality of the skin but also boosts the digestion.

Pros of Zesty Paws Coconut Oil for Dogs

Ø It is made up of only natural ingredients so that you don’t have to worry about toxic chemicals.

Ø Coconut oil provides all the vital vitamins and MCT fatty acids to keep the skin and the digestion healthy.

Ø It moisturizes the skin while nourishing the dog coats.

Ø It reduces itchiness and relieves the hot spots.

Ø It can be given to all types of dogs.


Ø An overdose of this lotion can be very harmful.

Ø There are cases where dogs’ conditions worsened after using this medicine.

7. Alpha Pet Zone Ultimate Pet Healer

Alpha Pet Zone coconut oil is one of the best repair and relief ointments for solving the problem of damaged and dry skin and for keeping the skin adequately moisturized.

It is made up natural substances and proves to be an ideal solution for itchiness caused by fleas and mites.

It soothes the dog’s skin by killing the fungus, yeasts, and other itchiness causing germs. It also reduces dandruff and you don’t need any extra dander spray.

The coconut oil provides antioxidants, vital vitamins, and MCT fatty acids that not only boost the immune system in dogs but also enhances their cognitive abilities.

You can apply the lotion on the rashes and hot spots of your dog or you can feed him with the food.

It is also effective in fighting infections, bad breaths, abrasions, and flaky dryness. It provides a pleasant tropical scent and keeps helps your dog look and smell great.

Pros of Alpha Pet Zone Pet Healer

Ø It provides better results as compared to other antibiotics and ointments.

Ø It kills mites, yeasts, fungus etc from the roots and thus eliminates the allergy completely.

Ø It maintains a fresh smell of your dog.

Ø It boosts the immune system and cognitive ability of your dog.

Ø It reduces dandruff and keeps the skin hydrated.

Ø It is made of hundred per cent organic substances.

Ø Since it also acts as a conditioner, you don’t need any extra dander spray.

Ø It is fit for cats as well.


Ø Overdose can be very dangerous.

Ø It shouldn’t be given to pregnant and lactating dogs.


The best way to deal with allergies is to follow discipline. Of course, your loving dog cannot understand this, but you can. Make sure that whatever treatment you follow, give your dog only the prescribed dose, neither less nor more. And if in case you suspect you’ve given an overdose, then seek the medical help immediately.

We hope that with this detailed article, we’ve helped you understand a lot about allergies in dogs and how can we treat them. While the benefits of apoquel come at the cost of side effects, there are other options too which you can choose from after consulting a veterinarian.

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